In obese adolescents, left ventricular septum thickness, left atrial diameter, mitral A-wave velocity, E/eвЂ™ ratio were significantly elevated ( pвЂ‰<вЂ‰0.05), as opposed to lean controls, while mitral eвЂ™-wave velocity was significantly lowered ( pвЂ‰<вЂ‰0.01).

Regression analyses were applied to examine relations between altered echocardiographic parameters and blood parameters or CPET parameters in the entire group. In 29 obese (BMI 31.6вЂ‰В±вЂ‰4.2вЂ‰kg/mВІ, age 13.4вЂ‰В±вЂ‰1.1 years) and 29 lean (BMI 19.5вЂ‰В±вЂ‰2.4вЂ‰kg/mВІ, age 14.0вЂ‰В±вЂ‰1.5 years) adolescents, fasted blood samples were collected to study hematology, biochemistry, liver function, glycemic control, lipid profile, and hormones, followed by a transthoracic echocardiography to assess cardiac structure/function, and a cardiopulmonary exercise test (CPET) to assess cardiopulmonary exercise parameters. Therefore,В we aimed to examine cardiac structure and function in obese adolescents, and to examine associations between altered cardiac function/structure and cardiometabolic disease risk factors or cardiopulmonary exercise capacity. To gain greater insights in the etiology and clinical consequences of altered cardiac function in obese adolescents.

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